Component of keto diet plus immunotherapy may reduce prostate cancer (Ketones from keto diet or supplement)

Medical Xpress / University of Notre Dame / Cancer Research ^ | April 27, 2024 | Deanna Csomo Ferrell / Sean Murphy et al

[ConservativeMind]

Adding a pre-ketone supplement—a component of a high-fat, low-carb ketogenic diet—to a type of cancer therapy in a laboratory setting was highly effective for treating prostate cancer, researchers found.

Prostate cancer is resistant to a type of immunotherapy called immune checkpoint blockade (ICB) therapy. ICB therapy paves the way for our body's fighter cells, T cells, to kill the cancer.

Murphy divided the models into different groups: immunotherapy alone, ketogenic diet alone, a pre-ketone supplement alone, the ketogenic diet with the immunotherapy, the supplement with the immunotherapy, and the control. While the immunotherapy alone had almost no effect on the tumors (just like what happens to most patients with prostate cancer), both the ketogenic diet with the immunotherapy and the pre-ketone supplement with the immunotherapy reduced the cancer and extended the lives of the mouse models.

The supplement with the immunotherapy worked best.

Lu said, "It made the tumor become very sensitive to the immunotherapy, with 23 percent of the mice cured—they were tumor-free; in the rest, the tumors were shrinking really dramatically."

The evidence points to the possibility that a supplement providing ketones, which are what is produced in the body when people eat a keto diet, might prevent the prostate cancer cells from being resistant to immunotherapy.

The success of this study is not about the lack of carbohydrates, Murphy and Lu stressed. It is about the presence of the ketone body, a substance produced by the liver and used as an energy source when glucose is not available. The ketones disrupt the cycle of the cancer cells, allowing the T cells to do their job to destroy them.

The successful therapy also reduced the number of a type of immune cell called neutrophils. Dysregulation of neutrophils is also associated with many other diseases.

[ConservativeMind]

Note that the ketogenic diet alone also reduced the cancer, but not as much as the ketone supplement with immunotherapy.

This would point to a keto diet possibly helping with prostate cancer, regardless of getting immunotherapy.

[ConservativeMind]

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